|Title:||Development of (Quantitative Structure-Activity Relationships models for nanoparticles|
|Abstract||The purpose of this project is to develop Quantitative Structure-Activity Relationships-models for engineered nanoparticles (QSARNP) that can predict the human health and environmental effect based on inherent physico-chemical properties of nanoparticles. Based on the hypothesis that the biological effects of engineered nanoparticles are directly linked to the inherent physico-chemical properties, the aim of this project is to provide guidance to companies, material developers, and regulators to screen and rank engineered nanoparticles according to their toxicity.
Within a two-year period, we will carry out research dedicated to the following objectives:
To identify and select appropriate human health and environmental toxicological endpoints and nanoparticle characteristics to be used as hazard descriptors
To develop and validate model(s) for estimation of the (eco)toxicity of engineered nanoparticles based on existing knowledge on physico-chemical properties and hazards documented in laboratory studies|